Cochran`s New Theory Of IQ Genetics
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April 11, 2012, 05:34 AM
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At West Hunter, Gregory Cochran writes about the distinction between extremely deleterious genetic mutations that frequently kill people before they pass on their bad gene (e.g., Huntington`s Disease) and mildly detrimental mutations that reduce Darwinian fitness in the range of 1 percent. Not surprisingly, the latter are more common because they can build up over the generations before they keep an individual from reproduciing.
... So… most  genetic load in humans is made up of many, many  mutations that each have fairly small effects.  A smaller fraction of the genetic load consists of mutations with big effects on fitness. 
... One important point is that a single highly deleterious mutation has a good chance of pushing the whole organism in some odd direction in phenotype space.  In other words, the same mutation that drops your IQ, or damages your heart, may also make you look funny.  At lower IQs, more and more kids are considered to suffer from ‘organic’ retardation.  On the other hand, a higher-than-average number of small-effect mutations should also interfere with really complex systems such as the brain (and reduce IQ), but because of the law of large numbers, wouldn’t tend to have any particular direction in phenotype space.  As far as I can tell, an extra-large dose of small-effect mutations, which we will henceforth call genetic noise, would not make you funny-looking.
Would the converse be true? Would good-looking but not very bright people also tend to have more genetic noise, as well, just in different places
Individuals can vary in the amount of genetic noise they carry, and populations can as well, depending on the relative intensity of selection and on the mutation rate, which might also differ.  For example, although having an unusually old father does not much affect the amount of genetic  noise an individual carries, a culture in which fathers were typically 55 would undoubtedly accumulate an unusually high amount of genetic noise, over a couple of millennia. 
If a kid’s parents have a higher-than-average amount of genetic noise, on average the kid will as well. This sure looks like what we usually call non-organic or familial retardation. 
Most of the within-population variation in IQ looks to be familial rather than organic.  If I’m right, this means that most IQ variation – what we might call the normal range – is caused by differences in the number of slightly deleterious mutations.  None of them would show up in a QTL search, because all are rare. And that is where we stand thus far:  no  intelligence QTLs have been found – although you never know what you’ll see in the next population.  On the other hand, shared chromosomal segments would mostly contain the same slightly deleterious mutations,  and so IQ should correlate with genetic similarity, which is what Visscher has found.
So, think of models for the genetics of IQ like horsepower in cars. In one model, a lot of people get the engine designed for 200 horsepower, some get the engine designed for 400 horsepower,  and some get the engine designed for 100 horsepower. Occasionally, something very bad happens in the manufacturing process or the maintenance process (e.g., Down`s Syndrome) and people get an engine that only delivers 50 horsepower. 
Cochran`s new model is at the other end of the spectrum: Most people get engines designed for 300 horsepower, but there are a whole lot of minor glitches in the manufacturing process (some because the blueprints have had accumulating errors creep into them in copying until they get thrown out, some de novo). So, most people get a mental engine somewhere in the 100 to 300 horsepower range, typically falling out in a bell curve. 
But what about the 400 horsepower people known to history?
Many great scientists and mathematicians have likely had relatively low levels of genetic noise combined with some fairly deleterious de novo mutations; with the net effect of a powerful mental engine strangely focused on some particular topic not directly related to fitness.  Low noise, high weirdness.   Math, not sheilas. One might look for advanced paternal age in such cases.
Read the whole thing there. There`s one phrase in it that hints at the next stage of his theory, but I`ll leave it at that.