In his dozen years of fame, Karl Rove has been wrong about a lot of things , most notably about the long term effects of immigration on the GOP. Karl was going to brilliantly manipulate immigrants into voting Republican to usher in an age of GOP dominance, like Mark Hanna did for William McKinley. 
But, few find unchanging realities (immigrants and their children mostly vote Democrat) terribly interesting or even respectable to think about, so Karl is still considered a major source of wisdom on this topic.
On the other hand, Karl was wrong on Election Night about one state, Ohio , for about an hour or two, and he may never live that down.
As you may recall, Obama jumped out to a sizable lead in early vote counting in Ohio, but then Romney started narrowing the gap as more votes came in. However, with 23 percent of the votes left to count and Obama up by only 991 votes in the official tally, Fox News called Ohio for the President, in effect calling the whole election. Rove vociferously protested that this call, like the dual wrong calls various networks made over Florida in 2000, was premature.
After awhile that night, it turned out the Fox analysts were right about Ohio and Rove was wrong, and Obama held on to win Ohio.
This is widely considered a humiliating catastrophe from which Rove's reputation may never recover. Because what everybody actually finds interesting are near toss-up competitions that will be over real soon so we can know who is the winner and who is the loser. The more random the result, the more exciting we find it.
So, Rove being wrong for 12 years about the impact of immigration on his Party ... mehhhhhh.
Rove being wrong for 120 minutes about one closely contested state ... what a loser!